The Vitamin E potency of Vitamin E TPGS is 387 IU/g, so the potency of Vitamin E TPGS, 20% solution is 77.4 IU/g. This TPGS solution has been used as a means of providing an easily absorbed form of Vitamin E.
Because Vitamin E TPGS is water-soluble while other forms of Vitamin E are fat-soluble, TPGS is absorbed by an entirely different mechanism. Fat-soluble Vitamin E requires the use of bile salts in the gut for absorption from the intestinal lumen through to the intestinal cells. Vitamin E TPGS is absorbed without the need for bile salts activity. TPGS has the ability of transferring Vitamin E into the intestinal cells with no need of assistance.
Along with assisting in Vitamin E absorption, the water-solubility of Vitamin E TPGS results in a product which is quite stable and does not hydrolyze under normal conditions. In addition, Vitamin E TPGS has practically no taste.
Typical Properties of Vitamin E TPGS, 20% Solution
|Molecular Weight, Vitamin E TPGS - Approximately 1513 |
Concentration, weight/weight - 20%
Taste - Practically tasteless
Vitamin E Content of Solution, mg/g - 52 as d-alpha tocopherol
Stability - Stable to air: Reacts with alkali
Size - 1 gallon jar, approximately 8.8 lb